In February 2021, the National Institutes of Health (NIH) announced the Researching COVID to Enhance Recovery (RECOVER) initiative to study the growing number of suspected, and in many cases potentially severe, post-acute sequelae of COVID (PASC).  

That May, NYU Langone was chosen as the project’s Clinical Science Core (CSC), responsible for leading and integrating the research activities of over 200 clinical sites and 40,000 study participants nationwide. The grant to NYU Langone represents one of the largest in NIH history. The CSC is helmed by co-principal investigators Stuart D. Katz, MD, the Helen L. and Martin S. Kimmel Professor of Advanced Cardiac Therapeutics; Leora Horwitz, MD, director of the Center for Healthcare Innovation and professor of Population Health and Medicine; and Andrea B. Troxel, ScD, director of the Division of Biostatistics and professor of Population Health.  

In consultation with more than 100 researchers from 35 institutions, as well as patients with PASC, the CSC designed the study protocols for RECOVER’s five cohorts. By January 2022, enrollment was underway for the adult, maternal-fetal medicine, autopsy, and electronic health record cohorts, with the pediatric cohort expected to follow later in the year.

“We’re asking basic questions about the pathophysiology, symptomology, and epidemiology of PASC. The answers will be crucial to solving a public health crisis affecting millions of people around the world.”  

Stuart D. Katz, MD